|
週次 |
日期 |
單元主題 |
|
第1週 |
|
Review on structure-and-function relationship |
|
第2週 |
|
Review on how structure research has impacted life sciences |
|
第3週 |
|
The field in biology that are being revolutionized by structures |
|
第4週 |
|
Taking picture of a macromolecule: image or diffraction |
|
第5週 |
|
Do we always need a crystal for X-ray diffraction? |
|
第6週 |
|
The advantage of electrons over X-ray and the bad side |
|
第7週 |
|
The radiation damage issue and the birth of cryo-EM |
|
第8週 |
|
The milestones of cryo-EM over last 30 years |
|
第9週 |
|
The phase contrast image formation and contrast transfer |
|
第10週 |
|
Midterm |
|
第11週 |
|
The reduction of contrast: charge-induced motion hypothesis |
|
第12週 |
|
Direct electron camera: motion correction |
|
第13週 |
|
Direct electron camera: DQE and Poisson noise |
|
第14週 |
|
Harvesting information from noisy single particle images |
|
第15週 |
|
Towards 3D reconstruction: Fourier-slice theorem |
|
第16週 |
|
Image alignment, model bias, and maximum likelihood |
|
第17週 |
|
What if there are multiple conformations? |
|
第18週 |
|
Final exam |